THE RESULTS OF THE EFFICACY AND SAFETY OF THE NEW RUSSIAN DRUG 6НР IN THE ANTIRETROVIRAL THERAPY REGIMENS OF HIV-INFECTED PATIENTS

Autor: A. V. Kravchenko, N. V. Sizova, S. V. Minaeva, O. A. Kozyrev, F. I. Nagimova, O. S. Efremova, D. A. Gusev, E. V. Ovsyannikova
Jazyk: ruština
Rok vydání: 2019
Předmět:
Zdroj: Журнал инфектологии, Vol 11, Iss 1, Pp 33-40 (2019)
Druh dokumentu: article
ISSN: 2072-6732
DOI: 10.22625/2072-6732-2019-11-1-33-40
Popis: The aim of the study was to assess the efficacy and safety of ART regimens that included different doses of the drug 6НР with the reception of QD, in comparison with the scheme of ART, containing, PhAZT, to select the daily dose 6НР in conducting phase III clinical trials.Patients and methods. 125 patients were randomized to 25 people in 4 groups, depending on the daily dose of the drug 6НР (600, 800, 1000, 1200 mg), and in the comparison group (phosphazide). For a daily dose of the drug 6НР the study was blind. All patients, in addition to the studied drugs were receiving 3TC and EFV. The effectiveness of ART regimens was assessed by the proportion of patients with HIV RNA
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