| Autor: |
Marini Mario, Panzeri Davide, Nardini Alessandra, Kariman Behjat S., Conci Claudio, Sironi Laura, Inverso Donato, Jacchetti Emanuela, Martinez Vázquez Rebeca, Osellame Roberto, Collini Maddalena, Cerullo Giulio, Raimondi Manuela Teresa, Kabouraki Elmina, Farsari Maria, Kehaghias Nikos, Tourlouki Konstantina, Chirico Giuseppe |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
EPJ Web of Conferences, Vol 309, p 04011 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2100-014X |
| DOI: |
10.1051/epjconf/202430904011 |
| Popis: |
Non-linear excitation microscopy offers superior in-vivo imaging but faces challenges in deep tissue. High numerical aperture beams suffer spherical aberrations, while tissue scattering impacts image quality. To address this, we propose implantable microlenses for precise focusing below the skin in lab animals. By using low numerical aperture lasers, we avoid spherical aberrations induced by high NA objectives. Our study presents various microlens designs differing in size, shape, and fabrication methods, all on glass or organo-hybrid ceramic substrates. This approach shows promise for enhancing deep tissue imaging, facilitating better understanding of biological processes in vivo. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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