Intravenous pathogenicity of influenza virus A/H5N1/2014 isolated from pig in Ogbomoso, Nigeria

Autor: E. Kolawole Oladipo, J. Kola Oloke, J. Adekunle Adeniji
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Open Veterinary Journal, Vol 8, Iss 3, Pp 347-350 (2018)
Druh dokumentu: article
ISSN: 2218-6050
DOI: 10.4314/ovj.v8i3.16
Popis: Understanding the pathogenicity of avian influenza viruses in poultry is an important scientific and public health challenge because of antigenic shift/drift and a source of novel, potentially human-pathogenic strains. We have previously isolated an influenza A strain (H5N1/2014/Ogbomoso) from an outbreak among pig and have now aimed to assess its pathogenicity in an avian host and to categorize it as a low or high pathogenic strain. Intravenous pathogenicity index of the isolated virus was assayed using experimental infection of 6 weeks old pathogen-specific free chicken. The peak of clinical signs was on day three post-infection, and one death was observed on day eight. The intravenous pathogenicity index of this isolate was 0.08. This results classify this isolate as a low pathogenic avian influenza strain.
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