| Autor: |
Xiaomin Liu, Xin Tong, Zhuye Jie, Jie Zhu, Liu Tian, Qiang Sun, Yanmei Ju, Leying Zou, Haorong Lu, Xuemei Qiu, Qiang Li, Yunli Liao, Heng Lian, Yong Zuo, Xiaomin Chen, Weiqiao Rao, Yan Ren, Yuan Wang, Jin Zi, Rong Wang, Xun Xu, Huanming Yang, Jian Wang, Yang Zong, Weibin Liu, Yong Hou, Xin Jin, Liang Xiao, Karsten Kristiansen, Huijue Jia, Tao Zhang |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
iScience, Vol 26, Iss 1, Pp 105839- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2589-0042 |
| DOI: |
10.1016/j.isci.2022.105839 |
| Popis: |
Summary: The oral microbiome has been implicated in a growing number of diseases; however, determinants of the oral microbiome and their roles remain elusive. Here, we investigated the oral (saliva and tongue dorsum) metagenome, the whole genome, and other omics data in a total of 4,478 individuals and demonstrated that the oral microbiome composition and its major contributing host factors significantly differed between sexes. We thus conducted a sex-stratified metagenome-genome-wide-association study (M-GWAS) and identified 11 differential genetic associations with the oral microbiome (psex-difference |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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