Mitophagy, metabolism, and cell fate
| Autor: | Lorena Esteban-Martínez, Elena Sierra-Filardi, Patricia Boya |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Molecular & Cellular Oncology, Vol 4, Iss 5 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2372-3556 23723556 |
| DOI: | 10.1080/23723556.2017.1353854 |
| Popis: | Mitophagy is the process by which cells eliminate damaged or superfluous mitochondria by degrading them within lysosomes. We show that during development, selective removal of mitochondria by autophagy induces a metabolic shift toward glycolysis that is essential for differentiation of several cell types. These findings suggest potential applications of cell-fate manipulation strategies targeting mitophagy. |
| Databáze: | Directory of Open Access Journals |
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