| Autor: |
Andressa Radiske, Maria Carolina Gonzalez, Janine I. Rossato, Gênedy Apolinário, João R. de Oliveira, Lia R. M. Bevilaqua, Martín Cammarota |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Molecular Brain, Vol 14, Iss 1, Pp 1-4 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1756-6606 |
| DOI: |
10.1186/s13041-021-00877-5 |
| Popis: |
Abstract Avoidance memory is destabilized when recalled concurrently with conflicting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible involvement in avoidance memory reconsolidation has not yet been studied. Using pharmacological, electrophysiological and optogenetic tools, we found that in adult male Wistar rats hippocampal CaMKII is necessary to reconsolidate avoidance memory, but not to keep it stored while inactive, and that blocking reconsolidation via CaMKII inhibition erases learned avoidance responses. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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