Radial peripapillary capillary density in superior segmental optic hypoplasia measured with OCT angiography

Autor: Maiko Abe, Kazuko Omodaka, Tsutomu Kikawa, Toru Nakazawa
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: BMC Ophthalmology, Vol 20, Iss 1, Pp 1-5 (2020)
Druh dokumentu: article
ISSN: 1471-2415
DOI: 10.1186/s12886-020-01453-6
Popis: Abstract Background To investigate the diagnostic power of radial peripapillary capillary (RPC) density, measured with optical coherence tomography angiography (OCT-A), in patients with superior segmental optic hypoplasia (SSOH). Methods Forty subjects with SSOH and 40 age- and axial length-matched control subjects were retrospectively registered for this study. SSOH was defined as intraocular pressure less than 21 mmHg with the presence of two of the following: superior rim thinning, superior entrance of the central retinal artery, scleral halo, and pale optic disc; as well as non-progressive visual field loss. RPC density was measured with swept-source OCT-A (Triton, Topcon) overall, in the quadrants, and in the 12 clock-wise sectors. Changes in RPC density were also compared in SSOH patients and age-matched patients with mild- or moderate-stage of glaucoma. RPC density was compared in pairs of groups with Welch’s t-test. Diagnostic power was assessed with the area under the receiver operating characteristics curve (AUC). Results Overall cpRNFLT was significantly different in the normal (106.7 ± 9.5 μm) and SSOH (77.2 ± 13.7 μm, p
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