Ultra‐high‐performance liquid chromatography‐quadrupole time‐of‐flight‐mass spectrometry‐characterized extract of Aerides odorata Lour alleviates paracetamol‐induced hepatotoxicity in animal model evidenced by biochemical, molecular, and computational studies

Autor: A. M. Abu Ahmed, Md. Atiar Rahman, Farjana Sharmen, A. S. M. Ali Reza, Md. Shahidul Islam, Md. Mamunur Rashid, Md. Khalid Juhani Rafi, Tanvir Ahmed Siddiqui, Md. Muzahid Ahmed Ezaj, Srabonti Saha, Md. Nazim Uddin, Walla Alelwani
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Animal Models and Experimental Medicine, Vol 7, Iss 4, Pp 497-522 (2024)
Druh dokumentu: article
ISSN: 2576-2095
DOI: 10.1002/ame2.12452
Popis: Abstract Background Many kinds of orchids have significant health benefits although adequate research on their biological functions is yet to be carried out. This study investigated the paracetamol‐induced liver damage–protecting effect of epiphytic Aerides odorata methanol extract (AODE). Methods The protective effects of AODE were studied by analyzing its effect on liver function parameters, messenger RNA (mRNA) expression, and tissue histopathological architecture. The results were confirmed by ligand–receptor interaction of molecular docking and multitarget interaction of network pharmacological analyses. Results AODE significantly (p
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