| Autor: |
Lana Y.M. Juee, Sargul H. Sofi, Aveen N. Adham |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Journal of Functional Foods, Vol 105, Iss , Pp 105550- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2023.105550 |
| Popis: |
M. officinalis a traditional herbal remedy used by local people of Kurdistan Region extract (250 and 500 mg/kg) investigated to study the gastroprotective efficacy using ethanol-induced gastric ulcer rats. Macroscopic study showed a significant decrement in ulcer index at high dose (500 mg/kg) (0.894 ± 0.07, P value ≤ 0.05) in comparison to both negative and positive control (omeprazole 20 mg/kg). Microscopical study confirm the potency of the plant (500 mg/kg) extract showed remarkable mucosal lesion improvement. The plant extract showed a great efficacy for decreasing the proinflammatory markers (TNF-α and IL-β1) (579.633 and 1184.873 pg/mL, respectively). M. officinalis plant expressed a significant capacity for scavenging DPPH free radicals (19.09 ± 0.71 µg/mL, P value ≤ 0.05). The phytochemical study showed an appreciable amount of tannin and flavonoids in the extract. The study observations candidate M. officinalis to be a potent gastroprotection agent. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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