Sodium nitroprusside as a nitric oxide donor in a rat intestinal ischemiareperfusion model

Autor: Ali Emre, Orhan Bayram, Bulent Salman, Sevim Ercan, Ziya Anadol, Okhan Akin
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Zdroj: Clinics, Vol 63, Iss 1, Pp 91-96 (2008)
Druh dokumentu: article
ISSN: 1807-5932
1980-5322
DOI: 10.1590/S1807-59322008000100016
Popis: AIM: The aim of this study was to investigate the efficacy of sodium nitroprusside in the reduction of the intestinal ischemiareperfusion injury as a nitric oxide donor after intraperitoneal administration. METHODS: The histopathological examinations and tissue malonyldialdehyde levels of 35 Wistar albino rats that were subjected to ischemia-reperfusion, were performed in 5 groups. The groups include Control, Ischemia -reperfusion, Sodium nitroprusside, NG-Nitro-L-Arginine Methyl Ester (L-NAME) and Sodium nitroprusside+L-NAME. Each rat was subjected to ischemia for 40 minutes and reperfusion for 30 minutes, except the control group. The medications were done intraperitoneally as saline 4 ml/kg, Sodium nitroprusside 5 mg/kg, L-NAME 10 mg/kg just before reperfusions. RESULTS: Significant tissue injury in histological sections and an increase in tissue levels of Malonyldialdehyde was detected in the I/R group. The efficacy of intraperitoneal administration of Sodium nitroprusside in both Sodium nitroprusside alone and Sodium nitroprusside+L-NAME groups was found statistically significant for the reducing of injury scores (p
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