| Autor: |
Martin Schultz, Line J. H. Rasmussen, Thomas Kallemose, Erik Kjøller, Morten N. Lind, Lisbet Ravn, Theis Lange, Lars Køber, Lars S. Rasmussen, Jesper Eugen-Olsen, Kasper Iversen |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, Vol 27, Iss 1, Pp 1-7 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1757-7241 |
| DOI: |
10.1186/s13049-019-0621-7 |
| Popis: |
Abstract Introduction Soluble urokinase plasminogen activator receptor (suPAR) is a prognostic and nonspecific biomarker associated with short-term mortality in emergency department (ED) patients. Therefore, the blood level of suPAR might be usable for identification of patients at high- and low risk, shortly after arrival at the ED. Here, we investigate the value of adding suPAR to triage and how this may impact on risk stratification regarding mortality. Methods The analyses were performed on the TRIAGE III cohort. Patients were triaged in four groups: Red, Orange, Yellow, and Green. Outcome was all-cause mortality within seven days. Discriminative abilities of triage and suPAR on mortality were assessed using the area under the curve (AUC) for receiver operating characteristics (ROC) curves. A suPAR cut-off value was generated using the Youden’s index. Patients were subsequently reclassified one triage level up if the suPAR level was above this cut-off and one level down if the suPAR level was below that value. Results The study included 4420 patients with an available triage category and suPAR measurement. suPAR was significantly better in predicting mortality than triage; AUC (95% confidence interval): 0.85 (0.80–0.89) vs. 0.71 (0.64–0.78), P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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