| Popis: |
Andréa Vasconcellos Batista da Silva,1 Sonia Alves Gouvea,2 Aurélio Paulo Batista da Silva,1 Saulo Bortolon,3 Anabel Nunes Rodrigues,2 Glaucia Rodrigues Abreu,2 Fernando Luiz Herkenhoff,2 1Department of Morphology, 2Department of Physiological Sciences, Health Sciences Center, 3Department of Technology, Informatic Center, Federal University of Espírito Santo, Vitoria, Espirito Santo, Brazil Background and objectives: Diabetic retinopathy is the main microvascular complication in diabetes mellitus and needs to be diagnosed early to prevent severe sight-threatening retinopathy. The purpose of this study was to quantify the retinal microvasculature pattern and analyze the influence of blood glucose level and the duration of diabetes mellitus on the retinal microvasculature. Methods: Two groups were analyzed: patients with diabetes (N=26) and patients without diabetes, ie, controls (N=26). A quantitative semiautomated method analyzed retinal microvasculature. The diameters of arterioles and venules were measured. The total numbers of arterioles and venules were counted. The ratio of arteriole diameter to venule diameter was calculated. The retinal microvasculature pattern was related to clinical and biochemical parameters. Results: Patients with diabetes exhibited larger venule diameters in the upper temporal quadrant of the retina compared to the lower temporal quadrant (124.85±38.03 µm vs 102.92±15.69 µm; P |
