Safety of different amphotericin B formulations among AIDS patients with invasive fungal disease: a retrospective observational study

Autor: Yuting Tan, Yanan Mo, Songjie Wu, Miao Tan, Shihui Song, Jie Liu, Hongying Yu, Ke Liang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: AIDS Research and Therapy, Vol 21, Iss 1, Pp 1-5 (2024)
Druh dokumentu: article
ISSN: 1742-6405
DOI: 10.1186/s12981-024-00649-w
Popis: Abstract We conducted a retrospective, observational study among acquired immune deficiency syndrome (AIDS) patients with cryptococcal meningitis or talaromycosis to assess AmB formulations-related adverse events (AEs). Total 205 eligible patients were enrolled. Of them, 139 received AmB therapy, 51 received liposomal AmB (L-AmB) therapy, and 15 received AmB cholesteryl sulfate complex (ABCD) therapy. The incidences of total AEs between the AmB, L-AmB and ABCD group had no significant differences. The ABCD group had significantly higher incidences of hepatotoxicity and hematological toxicity than the AmB and L-AmB groups. The incidence of grade 3–4 hematological toxicity in the ABCD group was significantly higher than that in the AmB and L-AmB groups. Multinomial logistic regression models showed that compared with AmB, ABCD had a higher risk for the occurrence of grade 3–4 hematological toxicity (aOR = 43.924, 95%CI 6.296-306.418; p
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