Targeting interleukin-10 signalling for cancer immunotherapy, a promising and complicated task
| Autor: | Guoying Ni, Lu Zhang, Xiaodan Yang, Hejie Li, Bowei Ma, Shelley Walton, Xiaolian Wu, Jianwei Yuan, Tianfang Wang, Xiaosong Liu |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Human Vaccines & Immunotherapeutics, Vol 16, Iss 10, Pp 2328-2332 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2164-5515 2164-554X 21645515 |
| DOI: | 10.1080/21645515.2020.1717185 |
| Popis: | Interleukin 10 (IL-10) belongs to IL-10 family cytokines that are critical for maintaining the integrity of epithelial tissues, protecting pathogenic infection, and preventing excessive immune responses to damage self. Temporal IL-10 signaling blockade enhances vaccine-induced tumor regression by CD8 + T cells. IL-10, especially pegylated IL-10, mediates tumor regression by expanding tumor-infiltrating CD8 + T cells. Moreover, targeting IL-10 enhances immune checkpoint inhibitor mediated tumor regression. In the current paper, we will review recent advances in this area and discuss the complexity of IL-10 manipulation for cancer therapy. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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