Intravenous Lipid Emulsions Affect Respiratory Outcome in Preterm Newborn: A Case-Control Study

Autor: Giovanni Boscarino, Maria Giulia Conti, Francesca De Luca, Maria Di Chiara, Giorgia Deli, Marco Bianchi, Paola Favata, Viviana Cardilli, Giovanni Di Nardo, Pasquale Parisi, Gianluca Terrin
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nutrients, Vol 13, Iss 4, p 1243 (2021)
Druh dokumentu: article
ISSN: 2072-6643
DOI: 10.3390/nu13041243
Popis: (1) Background: Hypertriglyceridemia (HiTG) is a metabolic complication of intravenous lipid emulsions (ILEs) infusion. We aimed to evaluate the influence of HiTG on the respiratory outcome of preterm babies; (2) Methods: We enrolled, in a case–control study, newborns with gestational age 150 mg/dL; (3) Results: We enrolled 40 cases and 105 controls. Cases had an increased incidence of bronchopulmonary dysplasia (30.0% vs. 14.3%, p < 0.05) and longer duration of invasive mechanical ventilation (7 days, 95% CI 4–10 days vs. 4 days, 95% CI 1–7 days, p < 0.01) compared to controls. Multivariate analysis confirmed that HiTG independently influenced the duration of invasive mechanical ventilation, also in the subgroups with gestational age ≤28 + 6/7 weeks or birth weight ≤1000 g; (4) Conclusion: Newborns with HiTG related to ILEs had a longer duration of invasive mechanical ventilation. Temporary suspension or reduction in ILEs in the case of HiTG is associated with an improvement of respiratory outcome.
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