Reproducibility and responsiveness of the Frailty Index and Frailty Phenotype in older hospitalized patients

Autor: Marlies Feenstra, Frederike M.M. Oud, Carolien J. Jansen, Nynke Smidt, Barbara C. van Munster, Sophia E. de Rooij
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: BMC Geriatrics, Vol 21, Iss 1, Pp 1-10 (2021)
Druh dokumentu: article
ISSN: 1471-2318
DOI: 10.1186/s12877-021-02444-y
Popis: Abstract Background There is growing interest for interventions aiming at preventing frailty progression or even to reverse frailty in older people, yet it is still unclear which frailty instrument is most appropriate for measuring change scores over time to determine the effectiveness of interventions. The aim of this prospective cohort study was to determine reproducibility and responsiveness properties of the Frailty Index (FI) and Frailty Phenotype (FP) in acutely hospitalized medical patients aged 70 years and older. Methods Reproducibility was assessed by Intra-Class Correlation Coefficients (ICC), standard error of measurement (SEM) and smallest detectable change (SDC); Responsiveness was assessed by the standardized response mean (SRM), and area under the receiver operating characteristic curve (AUC). Results At baseline, 243 patients were included with a median age of 76 years (range 70–98). The analytic samples included 192 and 187 patients in the three and twelve months follow-up analyses, respectively. ICC of the FI were 0.85 (95 % confidence interval [CI]: 0.76; 0.91) and 0.84 (95% CI: 0.77; 0.90), and 0.65 (95% CI: 0.49; 0.77) and 0.77 (95% CI: 0.65; 0.84) for the FP. SEM ranged from 5 to 13 %; SDC from 13 to 37 %. SRMs were good in patients with unchanged frailty status (
Databáze: Directory of Open Access Journals