Pla2g2a Attenuates Colon Tumorigenesis in Azoxymethane-Treated C57BL/6 Mice; Expression Studies Reveal Pla2g2a Target Genes and Pathways
Autor: | Remond J. A. Fijneman, Lindsey K. Bade, Johannes R. Peham, Mark A. van de Wiel, Victor W. M. van Hinsbergh, Gerrit A. Meijer, Michael G. O’Sullivan, Robert T. Cormier |
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Jazyk: | angličtina |
Rok vydání: | 2009 |
Předmět: | |
Zdroj: | Cellular Oncology, Vol 31, Iss 5, Pp 345-356 (2009) |
Druh dokumentu: | article |
ISSN: | 1570-5870 1875-8606 |
DOI: | 10.3233/CLO-2009-0480 |
Popis: | Background: The group IIA secretory phospholipase A2 gene, Pla2g2a, confers resistance to intestinal tumorigenesis in the ApcMin/+ mouse model. However, it is unclear how Pla2g2a exerts its tumor-suppressive effects and whether its mode of action depends on Apc-germline mutations. |
Databáze: | Directory of Open Access Journals |
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