Pla2g2a Attenuates Colon Tumorigenesis in Azoxymethane-Treated C57BL/6 Mice; Expression Studies Reveal Pla2g2a Target Genes and Pathways

Autor:	Remond J. A. Fijneman, Lindsey K. Bade, Johannes R. Peham, Mark A. van de Wiel, Victor W. M. van Hinsbergh, Gerrit A. Meijer, Michael G. O’Sullivan, Robert T. Cormier
Jazyk:	angličtina
Rok vydání:	2009
Předmět:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Cytology QH573-671
Zdroj:	Cellular Oncology, Vol 31, Iss 5, Pp 345-356 (2009)
Druh dokumentu:	article
ISSN:	1570-5870 1875-8606
DOI:	10.3233/CLO-2009-0480
Popis:	Background: The group IIA secretory phospholipase A2 gene, Pla2g2a, confers resistance to intestinal tumorigenesis in the ApcMin/+ mouse model. However, it is unclear how Pla2g2a exerts its tumor-suppressive effects and whether its mode of action depends on Apc-germline mutations.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/66aef155731f44db8bae098c9be18872 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF