| Autor: |
Rachel F Simpson, MB BCh, Carol Hermon, MSc, Bette Liu, DPhil, Jane Green, ProfDPhil, Gillian K Reeves, ProfPhD, Valerie Beral, ProfFRS, Sarah Floud, PhD |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
The Lancet Public Health, Vol 4, Iss 1, Pp e41-e48 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2468-2667 |
| DOI: |
10.1016/S2468-2667(18)30230-5 |
| Popis: |
Summary: Background: Alcohol is a known cause of cirrhosis, but it is unclear if the associated risk varies by whether alcohol is drunk with meals, or by the frequency or type of alcohol consumed. Here we aim to investigate the associations between alcohol consumption with meals, daily frequency of consumption, and liver cirrhosis. Methods: The Million Women Study is a prospective study that includes one in every four UK women born between 1935 and 1950, recruited between 1996 and 2001. In 2001 (IQR 2000–03), the participants reported their alcohol intake, whether consumption was usually with meals, and number of days per week it was consumed. Cox regression analysis yielded adjusted relative risks (RRs) for incident cirrhosis, identified by follow-up through electronic linkage to routinely collected national hospital admission, and death databases. Findings: During a mean of 15 years (SD 3) of follow-up of 401 806 women with a mean age of 60 years (SD 5), without previous cirrhosis or hepatitis, and who reported drinking at least one alcoholic drink per week, 1560 had a hospital admission with cirrhosis (n=1518) or died from the disease (n=42). Cirrhosis incidence increased with amount of alcohol consumed (≥15 drinks [mean 220 g of alcohol] vs one to two drinks [mean 30 g of alcohol] per week; RR 3·43, 95% CI 2·87–4·10; p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
