Low septal to lateral wall 18F-FDG ratio is highly associated with mechanical dyssynchrony in non-ischemic CRT candidates

Autor:	Ganna Degtiarova, Piet Claus, Jürgen Duchenne, Marta Cvijic, Georg Schramm, Johan Nuyts, Jens-Uwe Voigt, Olivier Gheysens
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Mechanical dyssynchrony Perfusion Metabolism Cardiac resynchronization therapy Positron emission tomography Medical physics. Medical radiology. Nuclear medicine R895-920
Zdroj:	EJNMMI Research, Vol 9, Iss 1, Pp 1-10 (2019)
Druh dokumentu:	article
ISSN:	2191-219X
DOI:	10.1186/s13550-019-0575-9
Popis:	Abstract Background In order to better understand the concept of mechanical dyssynchrony, a promising hallmark of cardiac resynchronization therapy (CRT) response, we investigated its effect on regional myocardial metabolism and myocardial blood flow (MBF) in non-ischemic CRT candidates. Results Thirty consecutive non-ischemic CRT eligible patients underwent static 18F-FDG and resting dynamic 13N-NH3 PET/CT. 18F-FDG uptake and MBF for septal and lateral wall were analysed and septal-to-lateral wall ratios (SLR) were calculated. Based on the presence of mechanical dyssynchrony (septal flash and/or apical rocking) on echocardiography, patients were divided into 2 groups, with (n = 23) and without (n = 7) mechanical dyssynchrony. Patients with mechanical dyssynchrony had significantly lower 18F-FDG SUVmean in the septum compared with the lateral wall (5.58 ± 2.65 vs 11.19 ± 4.10, p
Databáze:	Directory of Open Access Journals
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