A single-cell analysis reveals tumor heterogeneity and immune environment of acral melanoma

Autor: Chao Zhang, Hongru Shen, Tielong Yang, Ting Li, Xinyue Liu, Jin Wang, Zhichao Liao, Junqiang Wei, Jia Lu, Haotian Liu, Lijie Xiang, Yichen Yang, Meng Yang, Duan Wang, Yang Li, Ruwei Xing, Sheng Teng, Jun Zhao, Yun Yang, Gang Zhao, Kexin Chen, Xiangchun Li, Jilong Yang
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-34877-3
Popis: Studying the cell composition of acral melanoma at the single-cell level could provide some clues about its poor response to immunotherapy. Here, the authors analyse acral and cutaneous melanoma patient samples using single-cell RNA-sequencing, and reveal a severe immunosuppressive state in acral melanomas
Databáze: Directory of Open Access Journals