Marked paraneoplastic basophilia accompanying eosinophilia in a cat with alimentary T-cell lymphoma
| Autor: | Maria Balan, Aimee Hope, Joseph Cassidy, Maureen McCullough, Peter J O’Brien |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Journal of Feline Medicine and Surgery Open Reports, Vol 3 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2055-1169 20551169 |
| DOI: | 10.1177/2055116917730180 |
| Popis: | Case summary A 5-year-old male neutered domestic shorthair cat was referred with a history of persistent pyrexia, pica, soft faeces, inappetence, intermittent vomiting, mild-to-moderate granulocytosis and mild hypercalcaemia. No significant improvement was noted after antibiotic and corticosteroid treatment, except that the hypercalcaemia resolved. Physical examination, including thoracic auscultation, and abdominal and peripheral lymph node palpation, were unremarkable. On admission, haematology revealed moderate leukocytosis (36.8 × 10 9 /l) with moderate-to-marked eosinophilia (21.3 × 10 9 /l) and marked basophilia (4.04 × 10 9 /l), the latter identified microscopically. Lymphocytes were markedly decreased (0.37 × 10 9 /l). Blood smear examination revealed 58% eosinophils, 28% neutrophils, 11% basophils, 2% monocytes, 1% lymphocytes and marked, diffuse platelet clumping. Biochemistry abnormalities indicated mild pancreatitis, dehydration and anorexia with mildly increased pancreatic lipase, mild hypernatraemia (157 mmol/l), a moderate decrease in urea (3.1 mmol/l) and a slight decrease in phosphate (1.32 mmol/l). Ultrasound and radiographic imaging revealed enlargement of the mesenteric lymph nodes. Fine-needle aspiration, a Tru-cut biopsy and immunohistochemistry were performed. Cytological examination revealed ~65–75% lymphocytes (~80% were larger than a neutrophil), ~25–35% eosinophils and occasional basophils. Lymphocytes had single, small ( |
| Databáze: | Directory of Open Access Journals |
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