Antioxidant activity and hypoglycemic effect assessment of the leaves from Syzygium cumini (L.) Skeels in Wistar rats
| Autor: | Leise Nascimento Moreira, Jymmys Lopes dos Santos, Lúcio Marques Vieira Souza, Anderson Carlos Marçal, Antônio Santos Dias, Silvan Silva de Araújo, Brancilene Santos Araújo, Charles dos Santos Estevam |
|---|---|
| Jazyk: | English<br />Portuguese |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Acta Scientiarum. Health Sciences, Vol 43, Iss 1 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1679-9291 1807-8648 |
| DOI: | 10.4025/actascihealthsci.v43i1.52931 |
| Popis: | Syzygium cumini (L.) Skeels was adapted to the climatic conditions and soil types in Brazil. Its fruits, leaves and inner bark are used in folk medicine due to their high antioxidant, anti-inflammatory, anticarcinogenic and antidiabetic activities mainly associated with the presence of phenolic compounds. It is estimated that at least 300 million people worldwide develop diabetes and approximately 11 million people are carriers of the disease in Brazil. The objective of this work was to evaluate the in vitro antioxidant activity, as well as the hypoglycemic action of hydroethanolic extract (HEE), the ethyl acetate (EAF) and hydromethanolic (HMF) fractions from leaves of S. cumini (L.) Skeels in rats. All assays were carried out in three replications. Data were expressed as mean ± SD and significance was evaluated by ANOVA and Bonferroni test (p < 0.05). The results indicate a significant (p < 0.05) total phenol content (207 ± 2.3 GAE mg g-1) and antioxidant activity (EC50 = 9.05 ± 0.170 µg mL-1) for EAF. HEE and its fractions showed no significant (p > 0.05) action to modulate glucose by the OGTT assay in nondiabetic mice compared to control. Thus the use of the plant against diabetes in individuals is not proven. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|