Non-canonical Mechanisms of Presynaptic Kainate Receptors Controlling Glutamate Release

Autor: José V. Negrete-Díaz, Talvinder S. Sihra, Gonzalo Flores, Antonio Rodríguez-Moreno
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Frontiers in Molecular Neuroscience, Vol 11 (2018)
Druh dokumentu: article
ISSN: 1662-5099
DOI: 10.3389/fnmol.2018.00128
Popis: A metabotropic modus operandi for kainate receptors (KARs) was first discovered in 1998 modulating GABA release. These receptors have been also found to modulate glutamate release at different synapses in several brain regions. Mechanistically, a general biphasic mechanism for modulating glutamate release by presynaptic KARs with metabotropic actions has emerged, with low KA concentrations invoking an increase in glutamate release, whereas higher concentrations of KA mediate a decrease in the release of this neurotransmitter. The molecular mechanisms underpinning the opposite modulation of glutamate release are distinct, with a G-protein-independent, adenylate cyclase (AC)- and protein kinase A (PKA)-dependent mechanism mediating the facilitation of glutamate release, while a G-protein dependent mechanism (with or without protein kinase recruitment) is involved in the decrease of neurotransmitter release. In the present review, we revisit the mechanisms underlying the non-canonical modus operandi of KARs effecting the bimodal control of glutamatergic transmission in different brain regions, and address the possible functions that this modulation may support.
Databáze: Directory of Open Access Journals