Can a Biohybrid Patch Salvage Ventricular Function at a Late Time Point in the Post-Infarction Remodeling Process?

Autor: Lindemberg M. Silveira-Filho, MD, PhD, Garrett N. Coyan, MD, MS, Arianna Adamo, MS, Samuel K. Luketich, MS, Giorgio Menallo, BSc, MSc, Antonio D’Amore, PhD, William R. Wagner, PhD
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: JACC: Basic to Translational Science, Vol 6, Iss 5, Pp 447-463 (2021)
Druh dokumentu: article
ISSN: 2452-302X
DOI: 10.1016/j.jacbts.2021.01.004
Popis: Summary: A biohybrid patch without cellular components was implanted over large infarcted areas in severely dilated hearts. Nonpatched animals were assigned to control or losartan therapy. Patch-implanted animals responded with better morphological and functional echocardiographic endpoints, which were more evident in a subgroup of animals with very low pre-treatment ejection fraction (
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