| Autor: |
Yu-E Hao, Dong-Fang He, Rong-Hua Yin, Hui Chen, Jian Wang, Shao-Xia Wang, Yi-Qun Zhan, Chang-Hui Ge, Chang-Yan Li, Miao Yu, Xiao-Ming Yang |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
FEBS Open Bio, Vol 5, Iss 1, Pp 688-704 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
2211-5463 |
| DOI: |
10.1016/j.fob.2015.08.005 |
| Popis: |
G protein‐coupled receptor kinase interactor 2 (GIT2) is a signaling scaffold protein involved in regulation of cytoskeletal dynamics and the internalization of G protein‐coupled receptors (GPCRs). The short‐splice form of GIT2 is expressed in peripheral T cells and thymocytes. However, the functions of GIT2 in T cells have not yet been determined. We show that treatment with Con A in a model of polyclonal T‐lymphocyte activation resulted in marked inhibitions in the intrahepatic infiltration of inflammatory cells, cytokine response and acute liver failure inGit2−/− mice. CD4+ T cells fromGit2−/− mice showed significant impairment in proliferation, cytokine production and signal transduction upon TCR‐stimulated activation. Our results suggested that GIT2 plays an important role in T‐cell functionin vivo andin vitro. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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