Role of Th9 cells and Th17 cells in the pathogenesis of malignant ascites

Autor: Xian-Wen Yang, Hai-Xing Jiang, Xiao-Li Huang, Shi-Jia Ma, Shan-Yu Qin
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 10, Pp 806-811 (2015)
Druh dokumentu: article
ISSN: 2221-1691
DOI: 10.1016/j.apjtb.2015.07.013
Popis: Objective: To assess the role of Th9 and Th17 cells in malignant ascites (MA). Methods: MA from 30 hepatic carcinoma patients and benign ascites from 30 cirrhotic patients were collected. Corresponding peripheral blood samples from these hepatic carcinoma and cirrhotic patients as well as 30 healthy subjects were collected. The frequency of Th9 and Th17 cells was tested by flow cytometry. Serum levels of interleukin (IL)-9 and IL-17 were examined by ELISA. Results: The observed frequency of Th9 and Th17 cells, and the IL-9 and IL-17 serum levels were significantly higher in MA patients than those in cirrhotic patients and healthy control samples (P
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