| Autor: |
Elena Crehuá-Gaudiza, Ana Barrés Fernández, Carmen Jovaní Casano, María Latorre Tejerina, Ester María Largo Blanco, María Antonia Moreno Ruiz, Alicia Berghezan Suárez, Mónica García-Peris, Raquel Gil Piquer, Alicia Coret Sinisterra, Sandra Martínez-Barona, Cristina Salido-Capilla, María Ángeles Requena Fernández, Jose Vicente Arcos-Machancoses, Cecilia Martínez-Costa |
| Jazyk: |
Spanish; Castilian |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Anales de Pediatría (English Edition), Vol 94, Iss 4, Pp 223-229 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2341-2879 |
| DOI: |
10.1016/j.anpede.2020.07.012 |
| Popis: |
Introduction: European guidelines for the diagnosis of celiac disease (CD) have been updated in 2020. The primary objective was to review the compliance with the diagnostic criteria for CD, according to ESPGHAN 2012. Secondarily, to describe the clinical characteristics of the patients and to assess the changes that would be implied by the application of the new 2020 criteria. Patients and methods: Retrospective multicenter study in which 10 centers participated. Patients from 0 to 16 years old with a new diagnosis of CD in 2018–2019 were included. Clinical, serological variables and the performance of intestinal biopsy (IB) were collected. Results: 163 patients were included (57% female) with a median age of 7.6 years (SD 4.4). The form of presentation was: 47.8% classical, 30.7% no classical and 21.5% asymptomatic, with differences depending on age. Total IgA and anti-transglutaminase IgA antibodies were performed in all centers as the first diagnostic step. IgA anti-endomysial antibodies (EMA) were performed in 80%, and HLA haplotype in 95%. Of the total, 78 cases (47.9%) met criteria for not performing intestinal biopsy (IB). IB was indicated in the remaining 85 patients, but was not performed in 29 cases (17.8%). The performance of IB was lower in the secondary hospitals than in the tertiary ones (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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