Galectin-3 as a marker and mediator of endogenous inflammation and nitrosylation oxidative stress in patients with chronic heart failure
| Autor: | Yu. B. Shchukin, I. I. Berezin, E. A. Medvedeva, E. I. Seleznev, V. A. Dyachkov, L. N. Slatova |
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| Jazyk: | ruština |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Российский кардиологический журнал, Vol 0, Iss 2, Pp 45-49 (2013) |
| Druh dokumentu: | article |
| ISSN: | 1560-4071 2618-7620 |
| DOI: | 10.15829/1560-4071-2013-2-45-49 |
| Popis: | Aim. To investigate the association between plasma levels of galectin-3 and parameters of endogenous inflammation and nitrosylation oxidative stress (NOS) in patients with decompensated chronic heart failure (CHF). Material and methods. In total, 197 CHF patients with myocardial infarction in medical history were divided into 3 groups: Group 1 (n=56) with Functional Class (FC) II CHF IIA; Group 2 (n=72) with FC III CHF IIA; and Group 3 (n=69) with FC IV CHF IIB. The control group (CG) included 39 healthy individuals. Plasma levels of galectin-3, 3-nitrotyrosine, low-density lipoprotein (LDL) oxidation, EC-SOD activity, interleukin-6, and high-sensitivity C-reactive protein (hsCRP) were measured. Results. In Groups 1, 2, and 3, plasma levels of galectin-3 were significantly higher than in CG: by 39% (p |
| Databáze: | Directory of Open Access Journals |
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