| Autor: |
Xingbei Zhou, Tao Ding, Shushui Wang, Longping Wen |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Talanta Open, Vol 4, Iss , Pp 100059- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2666-8319 |
| DOI: |
10.1016/j.talo.2021.100059 |
| Popis: |
The feasibility of in vivo real-time monitoring of anti-factor Xa level had been explored using an integrated microdialysis-coupled microfluidic system. By customizing the dialysis membrane and utilizing a fluorogenic substrate, the performance of the integrated device was characterized and tested by continuous monitoring of the anti-factor Xa level in rats. Efficient sampling for low molecular weight heparin in the blood stream was demonstrated and the detection range of the device was determined to be 0.1-1.5 IU/ml. The anti-factor Xa profile was recorded for a period of 7 hours. Moreover, the results generated from this method agreed well with those from conventional assay. The present system provides a novel quantitative monitoring method with great precision, good reproducibility and full data coverage of treatment period. This study has paved the road for developing a bedside drug monitoring device in hospital setting. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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