Assembly of Nsp1 nucleoporins provides insight into nuclear pore complex gating.
| Autor: | Ramya Gamini, Wei Han, John E Stone, Klaus Schulten |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | PLoS Computational Biology, Vol 10, Iss 3, p e1003488 (2014) |
| Druh dokumentu: | article |
| ISSN: | 1553-734X 1553-7358 |
| DOI: | 10.1371/journal.pcbi.1003488 |
| Popis: | Nuclear pore complexes (NPCs) form gateways for material transfer across the nuclear envelope of eukaryotic cells. Disordered proteins, rich in phenylalanine-glycine repeat motifs (FG-nups), form the central transport channel. Understanding how nups are arranged in the interior of the NPC may explain how NPC functions as a selectivity filter for transport of large molecules and a sieve-like filter for diffusion of small molecules ( |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|