Introduction of HIV-2 and Multiple HIV-1 Subtypes to Lebanon
| Autor: | Danuta Pieniazek, James Baggs, Dale J. Hu, Ghassan M. Matar, Alexander M. Abdelnoor, Jacques E. Mokhbat, Marwan Uwaydah, Abdul Rahman Bizri, Artur Ramos, Luiz M. Janini, Amilcar Tanuri, Carol Fridlund, Charles Schable, Leo Heyndrickx, Mark A. Rayfield, Walid Heneine |
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| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: | |
| Zdroj: | Emerging Infectious Diseases, Vol 4, Iss 4, Pp 649-656 (1998) |
| Druh dokumentu: | article |
| ISSN: | 1080-6040 1080-6059 |
| DOI: | 10.3201/eid0404.980418 |
| Popis: | HIV genetic variability, phylogenetic relationships, and transmission dynamics were analyzed in 26 HIV-infected patients from Lebanon. Twenty-five specimens were identified as HIV-1 and one as HIV-2 subtype B. The 25 strains were classified into six env-C2-V3 HIV-1 subtypes: B (n = 10), A (n = 11), C (n = 1), D (n = 1), G (n = 1), and unclassifiable. Potential recombinants combining parts of viral regions from different subtypes Aenv/Dpol/Agag, Genv/Apol and the unclassifiable-subtypeenv/ unclassifiable-subtypepol/Agag were found in three patients. Epidemiologic analysis of travel histories and behavioral risks indicated that HIV-1 and HIV-2 subtypes reflected HIV strains prevalent in countries visited by patients or their sex partners. Spread of complex HIV-subtype distribution patterns to regions where HIV is not endemic may be more common than previously thought. Blood screening for both HIV-1 and HIV-2 in Lebanon is recommended to protect the blood supply. HIV subtype data provide information for vaccine development. |
| Databáze: | Directory of Open Access Journals |
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