Seroconversion of red blood cell antibody in ABO-incompatible living donor liver transplantation -a case report
| Autor: | Eun Kyung Lee, Insun Song, Gaab Soo Kim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Korean Journal of Anesthesiology, Vol 73, Iss 3, Pp 252-256 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2005-6419 2005-7563 |
| DOI: | 10.4097/kja.19141 |
| Popis: | Background Liver transplantation usually requires blood transfusion, and a red blood cell (RBC) antibody screen is essential for the prevention of a hemolytic reaction. Since proper ABO-compatible grafts are lacking, ABO-incompatible living donor liver transplantation (ABO-i LDLT) with desensitization is a feasible therapy. Desensitization includes intravenous rituximab injection and plasmapheresis before surgery. Case A 60-year-old female was diagnosed with hepatitis B virus-related hepatocellular carcinoma and planned for ABO-i LDLT. She tested positive in a RBC antibody screen over two years; however, she tested negative for the test after desensitization. Clinicians noted the seroconversion during induction, and thus, a delay in the preparation of adequate packed RBC was unavoidable. Conclusions Even when the latest RBC antibody screen is negative after immunosuppression, clinicians should consider the possibility of a prior positive result to promote safer medical treatment and management. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|