| Autor: |
J. Corbett, J. S. Young, M. J. Tipton, J. T. Costello, T. B. Williams, E. F. Walker, B. J. Lee, C. E. Stevens |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Journal of Physiological Sciences, Vol 73, Iss 1, Pp 1-24 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1880-6562 |
| DOI: |
10.1186/s12576-023-00882-4 |
| Popis: |
Abstract Heat acclimation/acclimatisation (HA) mitigates heat-related decrements in physical capacity and heat-illness risk and is a widely advocated countermeasure for individuals operating in hot environments. The efficacy of HA is typically quantified by assessing the thermo-physiological responses to a standard heat acclimation state test (i.e. physiological biomarkers), but this can be logistically challenging, time consuming, and expensive. A valid molecular biomarker of HA would enable evaluation of the heat-adapted state through the sampling and assessment of a biological medium. This narrative review examines candidate molecular biomarkers of HA, highlighting the poor sensitivity and specificity of these candidates and identifying the current lack of a single ‘standout’ biomarker. It concludes by considering the potential of multivariable approaches that provide information about a range of physiological systems, identifying a number of challenges that must be overcome to develop a valid molecular biomarker of the heat-adapted state, and highlighting future research opportunities. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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