Importance of TGFβ in Cancer and Nematode Infection and Their Interaction—Opinion

Autor:	Marta Maruszewska-Cheruiyot, Michael James Stear, Maja Machcińska, Katarzyna Donskow-Łysoniewska
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	TGFβ TGFβ mimic nematode cancer immunomodulation Microbiology QR1-502
Zdroj:	Biomolecules, Vol 12, Iss 11, p 1572 (2022)
Druh dokumentu:	article
ISSN:	2218-273X
DOI:	10.3390/biom12111572
Popis:	Historically, there has been little interaction between parasitologists and oncologists, although some helminth infections predispose to the development of tumours. In addition, both parasites and tumours need to survive immune attack. Recent research suggests that both tumours and parasites suppress the immune response to increase their chances of survival. They both co-opt the transforming growth factor beta (TGFβ) signalling pathway to modulate the immune response to their benefit. In particular, there is concern that suppression of the immune response by nematodes and their products could enhance susceptibility to tumours in both natural and artificial infections.
Databáze:	Directory of Open Access Journals
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