Effects of paeonol on proliferation and collagen synthesis of rat cardiac fibroblasts induced by aldosterone

Autor: Qian Xu, Li Na Wang, Jing Yi Zhao, Yan Hong Xiao, Chao Du
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Bangladesh Journal of Pharmacology, Vol 16, Iss 2 (2021)
Druh dokumentu: article
ISSN: 1991-0088
DOI: 10.3329/bjp.v16i2.51605
Popis: The aim of this study was to explore the possible molecular mechanisms of paeonol in preventing ventricular remodeling. The cell viability of neonatal rat cardiac fibroblasts was detected by the method of MTT. RT-PCR and Western blot were used to measure the expression of TGF-β1, type I collagen and type III collagen. After treating the cardiac fibroblasts with paeonol, the cell viability decreased (p
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