Increased mortality in patients with RA-associated interstitial lung disease: data from a French administrative healthcare database

Autor: Bruno Crestani, Philippe Dieude, Rene-Marc Flipo, Sebastien Ottaviani, Pierre-Antoine Juge, Lidwine Wemeau-Stervinou, Joe Zhuo
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: RMD Open, Vol 9, Iss 4 (2023)
Druh dokumentu: article
ISSN: 2056-5933
DOI: 10.1136/rmdopen-2023-003491
Popis: Objectives Interstitial lung disease (ILD) is a severe extra-articular manifestation of rheumatoid arthritis (RA). The objectives of this study were to estimate mortality rate in patients with RA-ILD and identify factors affecting mortality.Methods Data from a French national claims database (Système National des Données de Santé) from 2013 to 2018 were analysed. Adults with an RA diagnosis (International Classification of Diseases (ICD)-10 codes M05, M06.0, M06.8 and M06.9) were included. ILD diagnosis was defined with ICD-10 code J84. Mortality rates were compared between patients with RA with and without ILD, using Cox proportional hazards regression, after matching 1:1 for age, sex, age at RA-ILD onset and RA duration.Results Among 173 132 patients with RA, 4330 (3%) also had ILD (RA-ILD). After matching, RA-ILD was associated with an increased mortality rate (HR 3.4, 95% CI 3.1 to 3.9). The HR for mortality was greater for: patients aged
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