Lipoprotein(a), high-sensitivity c-reactive protein, homocysteine and cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis

Autor: Sarah O. Nomura, Harpreet S. Bhatia, Parveen K. Garg, Amy B. Karger, Weihua Guan, Jing Cao, Michael D. Shapiro, Michael Y. Tsai
Jazyk: angličtina
Rok vydání: 2025
Předmět:
Zdroj: American Journal of Preventive Cardiology, Vol 21, Iss , Pp 100903- (2025)
Druh dokumentu: article
ISSN: 2666-6677
DOI: 10.1016/j.ajpc.2024.100903
Popis: Background and aims: Elevated lipoprotein(a) [Lp(a)], high-sensitivity C-Reactive Protein (hs-CRP), and total homocysteine (tHcy) are associated with atherosclerotic cardiovascular disease (ASCVD) risk. This study investigated the individual and joint associations of Lp(a), hs-CRP and tHcy with coronary heart disease (CHD) and stroke. Methods: This study was conducted in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort (2000–2017) (CHD analytic N = 6,676; stroke analytic N = 6,674 men and women). Associations between Lp(a) (
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