A cross-sectional study of clinical and laboratory characteristics of systemic lupus erythematosus in tribal region of Jharkhand at RIMS, Ranchi

Autor: Ravi Kumar, Abhay Kumar, Usha Saroj, Madhusudan Kumar, Satyendra Kumar Singh, Awanish Kumar, Pramod Kumar Singh, Punam Kumari Munda, Anil Kumar Choudhary, Zobia Farheen
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Family Medicine and Primary Care, Vol 11, Iss 12, Pp 7836-7841 (2022)
Druh dokumentu: article
ISSN: 2249-4863
DOI: 10.4103/jfmpc.jfmpc_848_22
Popis: Objectives: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease of unknown etiology, mainly affecting female of child-bearing age group. Clinical scenario of SLE is not well defined in east region of India, especially in tribal region of Jharkhand. This article is mainly focused on clinical and laboratory characteristics of SLE in tribal region of Jharkhand. Materials and Methods: This was an analytical cross-sectional single-centered study conducted at RIMS, Ranchi, a tertiary care center of Jharkhand, between November 2020 and October 2021. A total 50 patients were diagnosed as SLE based on Systemic Lupus International Collaborating Clinics criteria. Results: Forty-five (90%) of patients in our study were female, with female to male ratio of 9:1. The mean age of presentation was 26.78 ± 8.12. Constitutional symptoms were found in 96% of patients, followed by anemia in 90% of patients. Renal involvement was found in 74% of patients, followed by polyarthritis (72%), malar rash (60%), and neurological manifestations (40%). Anti-nuclear antibody, anti-dsDNA, and anti-Smith antibodies were found positive in 100%, 84%, and 80% of patients, respectively. Conclusions: Clinical characteristics of SLE as per our study would help the health care professionals in this region to identify the disease at early stage and initiate appropriate treatment.
Databáze: Directory of Open Access Journals
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