| Autor: |
Kasereka Masumbuko Claude, Daniel Mukadi-Bamuleka, Kitenge-Omasumbu Richard, Katsuva Mbahweka Francois, Paluku Mwalitsa Jean Paul, Kavugho Muliwavyo, François Edidi-Atani, Meris Matondo Kuamfumu, Sabue Mulangu, Olivier Tshiani-Mbaya, Placide Mbala-Kingebeni, Steve Ahuka-Mundeke, Jean-Jacques Muyembe-Tamfum, Bonita E. Lee, Stan Houston, Zubia Mumtaz, Michael T. Hawkes |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
EBioMedicine, Vol 106, Iss , Pp 105241- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2352-3964 |
| DOI: |
10.1016/j.ebiom.2024.105241 |
| Popis: |
Summary: Background: Ebola virus disease (EVD) is associated with multisystem organ failure and high mortality. Severe hypoglycaemia is common, life-threatening, and correctable in critically ill patients, but glucose monitoring may be limited in EVD treatment units. Methods: We conducted a retrospective review of patients admitted to EVD treatment units in Butembo and Katwa, Eastern DRC. Glucose measurements were done using a handheld glucometer at the bedside or using the Piccolo xpress Chemistry Analyzer on venous samples. Findings: 384 patients (median age 30 years (interquartile range, IQR, 20–45), 57% female) and 6422 glucose measurements (median 11 per patient, IQR 4–22) were included in the analysis. Severe hypoglycaemia (≤2.2 mmol/L) and hyperglycaemia (>10 mmol/L) were recorded at least once during the ETU admission in 97 (25%) and 225 (59%) patients, respectively. A total of 2004 infusions of glucose-containing intravenous solutions were administered to 302 patients (79%) with a median cumulative dose of 175g (IQR 100–411). The overall case fatality rate was 157/384 (41%) and was 2.2-fold higher (95% CI 1.3–3.8) in patients with severe hypoglycaemia than those without hypoglycaemia (p = 0.0042). In a multivariable Cox proportional hazards model, periods of severe hypoglycaemia (adjusted hazard ratio (aHR) 6.2, 95% CI 3.2–12, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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