| Autor: |
Eiko Maeda, Akemi Koshiba, Taisuke Mori, Fumitake Ito, Hisashi Kataoka, Hiroyuki Okimura, Takuya Sugahara, Yosuke Tarumi, Izumi Kusuki, Khaleque N. Khan, Jo Kitawaki |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
European Journal of Obstetrics & Gynecology and Reproductive Biology: X, Vol 7, Iss , Pp 100108- (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2590-1613 |
| DOI: |
10.1016/j.eurox.2020.100108 |
| Popis: |
Objective: Chronic inflammation in endometriosis is associated with increased risk of future cardiovascular disease; however, no studies have investigated the cardiovascular risk of women who have undergone hormonal therapy for endometriosis. We investigated atherosclerosis-related biomarkers in women with and without endometriosis and the effects of dienogest (DNG) and oral contraceptive (OC) therapies. Study design: In this cross-sectional study, 109 women with endometriosis and 42 control women without endometriosis were enrolled. The endometriosis group was divided into the untreated (n = 34), DNG therapy (n = 33), and OC therapy (n = 42) groups. Lipid profile serum levels, inflammatory marker such as high-sensitivity C-reactive protein, oxidative stress markers such as oxidized low-density lipoprotein and diacron-reactive oxygen metabolites, and atherosclerosis indicators (cardio-ankle vascular index [CAVI] and ankle-brachial pressure index [ABI]) were measured. Results: The median treatment duration was 28 months in the DNG group and 32.5 months in the OC group. Triglyceride levels were higher in the OC group than in the other three groups (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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