Combination of antifungal agent and prebiotic for acute vulvovaginal candidiasis

Autor: Krotin P.N., Kirilenko O.V.
Jazyk: ruština
Rok vydání: 2019
Předmět:
Zdroj: РМЖ. Мать и дитя, Vol 2, Iss 2 (2019)
Druh dokumentu: article
ISSN: 2618-8430
2686-7184
Popis: Combination of antifungal agent and prebiotic for acute vulvovaginal candidiasis P.N. Krotin, O.V. Kirilenko City Consultative Diagnostic Center “Juventa”, St. Petersburg, Russian Federation Aim: To assess efficacy and safety of Ecofucin® vaginal suppositories based on the time to clinical and microbiological remission in women with acute vaginal or vulvovaginal candidiasis. Patients and Methods: The study enrolled women aged 18–45 with acute vaginal or vulvovaginal candidiasis. All patients were subdivided into 2 groups. Study group included 36 patients who received Ecofucin® vaginal suppositories (natamycin 100 mg plus lactulose 300 mg) once a day for 6 days. Control group included 36 patients who received Pimafucin® vaginal suppositories (natamycin 100 mg) once a day for 6 days. Efficacy and safety of medications were assessed by gynecological examination, laboratory tests, and patient diaries. Follow-up examinations were performed at days 4, 7, and 37 (±2 days) after treatment begins (30±2 days after treatment finishes). Results: Combination of antifungal medication (natamycin) and prebiotic in a vaginal suppository provides more rapid clinical remission and complete elimination of VVC causative agent thus resulting in active growth of lactobacilli, principal competitors of yeasts in vaginal microbiocoenosis. Conclusions: Good tolerability of Ecofucin® was demonstrated, no adverse reactions were reported. Keywords: vulvovaginal candidiasis, vaginal microbiocoenosis, lactobacilli. For citation: Krotin P.N., Kirilenko O.V. Combination of antifungal agent and prebiotic for acute vulvovaginal candidiasis. Russian Journal of Woman and Child Health. 2019;2(2):120–125.
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