Treatment strategies and treatment-related adverse events in MG according to the age of onset

Autor: João Moura, Joana Fernandes, Maria João Lima, Ana Paula Sousa, Raquel Samões, Ana Martins Silva, Ernestina Santos
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Neurology, Vol 15 (2024)
Druh dokumentu: article
ISSN: 1664-2295
DOI: 10.3389/fneur.2024.1277420
Popis: IntroductionEarly-onset (EOMG) and late-onset (LOMG) are distinct groups of MG patients. It is unclear if treatment strategies and treatment-related adverse events may differ according to the age of MG onset.MethodsThis single-center retrospective study includes all MG patients followed at a tertiary center since 2007. We reviewed the electronic clinical records.ResultsIn total, 212 patients were identified, 142 (67.0%) females, with a median disease duration of 10 years. The median age of symptom onset was 42.0 (26.0–64.5) years, with 130 (61.3%) EOMG cases and 82 (38.7%) LOMG. EOMG were more frequently female, had longer disease duration and often more generalized MG (p
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