Hepatocyte growth factor and carotid intima-media thickness in relation to circulating CD34-positive cell levels

Autor: Yuji Shimizu, Shimpei Sato, Jun Koyamatsu, Hirotomo Yamanashi, Mako Nagayoshi, Shin-Ya Kawashiri, Keita Inoue, Shoichi Fukui, Hideaki Kondo, Seiko Nakamichi, Yasuhiro Nagata, Takahiro Maeda
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Environmental Health and Preventive Medicine, Vol 23, Iss 1, Pp 1-8 (2018)
Druh dokumentu: article
ISSN: 1342-078X
1347-4715
DOI: 10.1186/s12199-018-0705-4
Popis: Abstract Background Hepatocyte growth factor (HGF) may act as a possible biochemical index for vascular damage, although evidence for the association between HGF and carotid intima-media thickness (CIMT) is limited. Since both HGF and circulating CD34-positive cells play an important role in endothelial repair, circulating CD34-positive cell levels may influence the association between HGF and CIMT. Methods We conducted a cross-sectional study of 269 elderly Japanese men aged 60–69 years who had undertaken an annual medical checkup from 2014 to 2015. Results The median value for circulating CD34-positive cells was 0.93 cells/μL. Among the study population, 135 men showed low circulating CD34-positive cell levels (≤ 0.93 cells/μL). By multivariable linear regression analysis, HGF was found to be significantly positively associated with CIMT only to participants with low circulating CD34-positive cell levels, with a multi-adjusted β of 0.26 (p = 0.005) and 0.002 (0.986) for low and high circulating CD34-positive cell levels, respectively. In addition, a significant interaction was observed between HGF and circulating CD34-positive cell levels (low and high) on CIMT (multivariable p value of 0.049). A positive association exists between HGF and CIMT in elderly Japanese men, limited to participants with low circulating CD34-positive cell levels. Conclusion A positive association exists between HGF and CIMT in community-dwelling elderly Japanese men, which is limited to participants with low numbers of circulating CD34-positive cells. Our findings indicate that circulating CD34-positive cell levels could determine the influence of HGF on CIMT in elderly Japanese men.
Databáze: Directory of Open Access Journals
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