A low‐intensity 10‐min resistance exercise program that ameliorated hepatic fibrosis indices and altered G‐CSF/IP‐10/PDGF‐BB in a patient with nonalcoholic fatty liver disease: A case report

Autor: Ryuki Hashida, Dan Nakano, Hiroo Matsuse, Sachiyo Yoshio, Tsubasa Tsutsumi, Machiko Kawaguchi, Shunji Koya, Keisuke Hirota, Hiroshi Tajima, Yoshio Sumida, Tatsuya Kanto, Takumi Kawaguchi, Koji Hiraoka
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: JGH Open, Vol 7, Iss 3, Pp 231-234 (2023)
Druh dokumentu: article
ISSN: 2397-9070
DOI: 10.1002/jgh3.12876
Popis: Abstract We developed a low‐intensity 10‐min resistance exercise program for nonalcoholic fatty liver disease (NAFLD). We report a case of NAFLD with elevated hepatic fibrosis indices, which were improved by a 60‐week daily exercise program. A 71‐year‐old female patient with NAFLD whose hepatic fibrosis stage corresponded to F2 was referred to our hospital. She performed the exercise once a day with no changes in other lifestyle habits and medications. The homeostasis model assessment‐insulin resistance value and NAFLD‐liver fat score, the Hepamet fibrosis score, and the enhanced liver fibrosis score decreased. The FIB‐4 index and serum levels of Mac‐2 binding protein glycosylation isomer decreased to the reference values. We investigated the changes in chemokines/cytokines. The serum granulocyte‐colony stimulating factor level was increased, and serum interferon‐gamma‐induced protein‐10 and platelet‐derived growth factor‐BB levels were decreased. Our program may be beneficial for improving hepatic fibrosis in patients with NAFLD.
Databáze: Directory of Open Access Journals