Changes in vitamins and trace elements after initiation of highly effective CFTR modulator therapy in children and adults with cystic fibrosis – a real-life insight

Autor:	Dorit Fabricius, Tina Knieling, Noelle Zurmuehl, Leandra Makedon, Joachim Freihorst, Hanna Schmidt, Sebastian Bode
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Cystic fibrosis Vitamins Trace elements Micronutrients Highly effective CFTR modulator therapy Individualized therapy Pediatrics RJ1-570
Zdroj:	Molecular and Cellular Pediatrics, Vol 11, Iss 1, Pp 1-11 (2024)
Druh dokumentu:	article
ISSN:	2194-7791
DOI:	10.1186/s40348-024-00178-6
Popis:	Abstract Background Highly-effective CFTR-modulator therapy with elexa-/teza-/ivacaftor (ETI) has led to improvements in pulmonary outcomes, sweat chloride, body mass index (BMI) and quality of life in people with cystic fibrosis (CF). Improved uptake of fat-soluble vitamins and micronutrients has been reported for CFTR-modulators but data regarding ETI therapy is lacking. Methods This single-center retrospective study evaluated forced expiratory volume in one second (FEV-1), sweat chloride, BMI, transaminases (AST, ALT), bilirubin, vitamins A, D, E, zinc and selenium in children and adults eligible for ETI. Parameters were assessed before and up to one year after initiation of ETI. Results 58 patients (median age m = 28 years, SD ± 11.6 years, 51.7% female14
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/65b412cccdaf48c99e9aa37d8d881ccc Zobrazit plný text záznamu Full text from SpringerLink View record in DOAJ