Glycemic traits and colorectal cancer survival in a cohort of South Korean patients: A Mendelian randomization analysis

Autor:	So Yon Jun, Sooyoung Cho, Min Jung Kim, Ji Won Park, Seung‐Bum Ryoo, Seung Yong Jeong, Kyu Joo Park, Aesun Shin
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	colorectal cancer glycemic traits Mendelian randomization analysis Type 2 diabetes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Cancer Medicine, Vol 13, Iss 5, Pp n/a-n/a (2024)
Druh dokumentu:	article
ISSN:	2045-7634
DOI:	10.1002/cam4.7084
Popis:	Abstract Background Clinical diabetic traits have been reported to be associated with increased colorectal cancer (CRC) risk in observational studies. Using the Mendelian randomization (MR) analysis method, we examined the causal association between glycemic traits, such as fasting glucose (FG), fasting insulin (FI), and glycosylated hemoglobin A1c (HbA1c), and survival in a cohort of CRC patients. Methods We conducted a two‐sample MR analysis among a cohort of patients with locally advanced CRC at Seoul National University Hospital. Single‐nucleotide polymorphisms robustly associated (p
Databáze:	Directory of Open Access Journals
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