Association of Circular RNAs levels in blood and Essential Hypertension with Carotid Plaque
| Autor: | Haiyan Qian, Zebo Zhang, Zhenbo Tao, Yanqing Xie, Yueqi Yin, Wenming He, Lina Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Clinical and Experimental Hypertension, Vol 45, Iss 1 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1064-1963 1525-6006 10641963 |
| DOI: | 10.1080/10641963.2023.2180020 |
| Popis: | Background As one of the essential hypertension (EH)-mediated target organ damage, carotid plaque is a crucial subclinical precursor for cardiovascular events. Therefore, it is vital to identify the risk factors and pathogenesis for EH with carotid plaque. Methods Based on our previous microarray analysis, we selected four circRNAs as the candidate circRNAs and detected their expression levels in blood of 192 subjects (64 healthy controls, 64 EH patients, and 64 EH patients with carotid plaque) by qRT-PCR analysis. The regulatory mechanism of circRNAs involved in carotid plaque was predicted by bioinformatics analysis. Results The level of hsa_circ_0124782 increased significantly and the levels of hsa_circ_0131618 and hsa_circ_0127342 decreased significantly in the EH group and EH with carotid plaque group compared with the control group (P |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|