| Autor: |
Jingwei Jiang, Xinyi Shao, Weiwei Liu, Mengyue Wang, Qiwei Li, Miaomiao Wang, Yang Xiao, Ke Li, Huan Liang, Nian’ou Wang, Xuegang Xu, Yan Wu, Xinghua Gao, Qiaoli Xie, Xiao Xiang, Wanqian Liu, Wang Wu, Li Yang, Zhong-Ze Gu, Jin Chen, Mingxing Lei |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Cell Reports, Vol 43, Iss 7, Pp 114513- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2211-1247 |
| DOI: |
10.1016/j.celrep.2024.114513 |
| Popis: |
Summary: Psoriasis is an intractable immune-mediated disorder that disrupts the skin barrier. While studies have dissected the mechanism by which immune cells directly regulate epidermal cell proliferation, the involvement of dermal fibroblasts in the progression of psoriasis remains unclear. Here, we identified that signals from dendritic cells (DCs) that migrate to the dermal-epidermal junction region enhance dermal stiffness by increasing extracellular matrix (ECM) expression, which further promotes basal epidermal cell hyperproliferation. We analyzed cell-cell interactions and observed stronger interactions between DCs and fibroblasts than between DCs and epidermal cells. Using single-cell RNA (scRNA) sequencing, spatial transcriptomics, immunostaining, and stiffness measurement, we found that DC-secreted LGALS9 can be received by CD44+ dermal fibroblasts, leading to increased ECM expression that creates a stiffer dermal environment. By employing mouse psoriasis and skin organoid models, we discovered a mechano-chemical signaling pathway that originates from DCs, extends to dermal fibroblasts, and ultimately enhances basal cell proliferation in psoriatic skin. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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