Comparison of Two Nomograms of Unfractionated Heparin in Patients with Acute Coronary Syndrome
| Autor: | Moneyreh Modares Mosadegh, Seyed Mahmood Sadr Bafghi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Acta Medica Iranica, Vol 51, Iss 2, Pp 87-93 (2013) |
| Druh dokumentu: | article |
| ISSN: | 0044-6025 1735-9694 |
| Popis: | Heparin has an unpredictable pharmacokinetics and the responses of individuals may vary distinctly. Therefore, different dosing nomograms have been proposed. The aim of this study was to compare two prevalent nomograms to adjust heparin doses in hospitalized patients with acute coronary syndrome. One hundred and forty patients received heparin infusions based on one of two nomograms. Group 1 received a bolus of 80 U/Kg/h and an initial infusion rate of 17 U/Kg/h. In the second group, a bolus of 60 U/Kg (maximum of 4000 U) and an initial infusion rate of 12 U/Kg/h (maximum of 900U/h) was given. Activated partial thromboplastin time (aPTT) was measured at the beginning and every 6 h for 48 hours. The rate of heparin was changed according to each nomogram in order to maintain aPTT in the therapeutic level of 46-70 s. The time to pass threshold was on average 7.63±3.95 h for nomogram 1 and 11.05±4.41 h for the second nomogram (P |
| Databáze: | Directory of Open Access Journals |
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