Efficacy and safety of advanced hybrid closed loop systems in children with type 1 diabetes younger than 6 years
| Autor: | Novella Rapini, Mariangela Martino, Claudia Arnaldi, Annalisa Deodati, Lilian Anagnostopoulou, Maria Elisa Amodeo, Paolo Ciampalini, Valentina Pampanini, Antonella Lorubbio, Davide Tosini, Stefano Cianfarani, Riccardo Schiaffini |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Frontiers in Endocrinology, Vol 15 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1664-2392 24919446 |
| DOI: | 10.3389/fendo.2024.1382920 |
| Popis: | BackgroundTight glycemic control is essential for the normal growth and development of preschool children. The aim of our study was to evaluate the impact of advanced hybrid closed loop (AHCL) systems in a real-life setting in children younger than 6 years.MethodsWe conducted a two-center prospective study. We enrolled 19 patients with a median age at disease onset of 2.6 years [interquartile range (IQR) 1.6; 4.4] and a median disease duration of 1.4 years (IQR 0.9; 2.8) who were switched to AHCL from multiple daily injections or open-loop insulin therapy and with a 6-month follow-up. Clinical data, sensor glycemic metrics, and pump settings were collected and analyzed.ResultsAfter 6 months of follow-up, there was a significant reduction in median HbA1c (p = 0.0007) and glucose management indicator (p = 0.03). A reduction in both mild (>180 mg/dL) (p = 0.04) and severe (>250 mg/dL) (p = 0.01) hyperglycemia was observed after 1 month of auto mode, and in mild hyperglycemia, it persisted up to 6 months (p = 0.02). A small increase in time below range ( |
| Databáze: | Directory of Open Access Journals |
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